Mucosal B Cell Deficiency in IgA
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چکیده
منابع مشابه
Effect of methionine deficiency on duodenal and jejunal IgA+ B cell count and immunoglobulin level of broilers
Dietary methionine (met) is reported to enhance antibody production and boost cell-mediated immunity in chickens. Methionine deficiency has been shown to affect the development of the lymphoid organs and the generation of antibodies in chickens. This study is designed to investigate the effects of met deficiency on IgA+ B cells and immunoglobulins (sIgA, IgA, IgG and IgM) for a 6 wee...
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IgA selective deficiency is the most common immunodeficiency. The prevalence of it in different races varies from to . Since secretary IgA has has a defensive role in the mucosal surfaces, supposing is thought that IgA deficiency will be accompanied by oral manifestations. The previous studies showed controversial results about that. The aim of this cohort study was to finding out oral manifes...
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This study was performed in 77 HIV1 seropositive adult patients to characterise the IgA hyperglobulinaemia seen in the serum during the course of HIV infection. It was shown that both IgA1 and IgA2 subclass concentrations were simultaneously increased but the IgA1 increase was predominant. Secretory IgA (SIgA) concentration was significantly increased and IgA activity to gliadin, bovine serum a...
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Though it has been shown that TGF-beta 1 directs B cells to switch to IgA in vitro, no studies have assessed TGF-beta 1 effects on mucosal vs systemic immunity in vivo. When the B cell functions of TGF-beta 1 gene-disrupted (TGF-beta 1-/-) mice were analyzed, significantly decreased IgA levels and increased IgG and IgM levels in serum and external secretions were observed. Further, analysis of ...
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In this Research Topic of Frontiers in Mucosal Immunology we have focused on gut IgA B cell responses. We have invited world leading researchers in the field to contribute with articles that give the most recent up-date on our current understanding of this interesting and complex protective system. Because a majority of all human pathogens access the body via the mucosal membranes we need an ef...
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